Vascular smooth muscle relaxation by alpha-adrenoceptor blocking action of dobutamine in isolated rabbit aorta.

@article{Aikawa1996VascularSM,
  title={Vascular smooth muscle relaxation by alpha-adrenoceptor blocking action of dobutamine in isolated rabbit aorta.},
  author={J i Aikawa and Masayuki Fukazawa and Masaaki Ishikawa and Masao Moroi and Atsushi Namiki and Tsuyoshi Yamaguchi},
  journal={Journal of cardiovascular pharmacology},
  year={1996},
  volume={27 1},
  pages={33-6}
}
We investigated the mechanism of vascular relaxation produced by dobutamine, a positive inotropic agent with beta 1-adrenergic action. Dobutamine concentration-dependently (10 nM-10 microM) relaxed ring segments of rabbit aorta partially precontracted with 1 microM phenylephrine (PE) but did not relax those precontracted with 40 mM K+ or 5 microM prostaglandin F2 alpha (PGF2 alpha). The relaxation was not completely inhibited by pretreatment with 10 microM propranolol. Dobutamine did not… CONTINUE READING