Vascular smooth muscle cells in atherosclerosis

  title={Vascular smooth muscle cells in atherosclerosis},
  author={Gemma Basatemur and Helle F. J{\o}rgensen and Murray C H Clarke and M. Bennett and Z. Mallat},
  journal={Nature Reviews Cardiology},
  • Gemma Basatemur, Helle F. Jørgensen, +2 authors Z. Mallat
  • Published 2019
  • Medicine
  • Nature Reviews Cardiology
  • Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the ‘response to injury’ and ‘vulnerable plaque’ hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and hence stabilize plaques. However, lineage-tracing studies have highlighted flaws in the interpretation of former studies, revealing that these… CONTINUE READING
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