Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.

@article{CrosasMolist2015VascularSM,
  title={Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.},
  author={Eva Crosas-Molist and Thayna Meirelles and Judit L{\'o}pez-Luque and Carla Serra-Peinado and Javier Selva and Laia Caja and Darya Gorbenko del Blanco and Juan Jos{\'e} Uriarte and Esther Bertr{\'a}n and Yolanda Mendiz{\'a}bal and Vanessa Hern{\'a}ndez and Carolina Garc{\'i}a-Calero and {\'O}scar Busnadiego and Enric Condom and David Toral and Manel Castell{\'a} and Alberto Forteza and Daniel Navajas and Elisabet Sarri and Fernando Rodr{\'i}guez-Pascual and Harry C Dietz and Isabel Fabregat and Gustavo Egea},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 4},
  pages={960-72}
}
OBJECTIVE Marfan's syndrome is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic tissue growth factor (TGF)-β signaling. TGF-β is a potent regulator of the vascular smooth muscle cell (VSMC) phenotype. We hypothesized that as a result of the chronic TGF-β signaling, VSMC would alter their basal differentiation phenotype, which could facilitate the formation of aneurysms. This study explores whether… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…