Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.

  title={Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.},
  author={Eva Crosas-Molist and Thayna Meirelles and Judit L{\'o}pez-Luque and Carla Serra-Peinado and Javier Selva and Laia Caja and Darya Gorbenko del Blanco and Juan Jos{\'e} Uriarte and Esther Bertr{\'a}n and Yolanda Mendiz{\'a}bal and Vanessa Hern{\'a}ndez and Carolina Garc{\'i}a-Calero and {\'O}scar Busnadiego and Enric Condom and David Toral and Manel Castell{\'a} and Alberto Forteza and Daniel Navajas and Elisabet Sarri and Fernando Rodr{\'i}guez-Pascual and Harry C Dietz and Isabel Fabregat and Gustavo Egea},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={35 4},
OBJECTIVE Marfan's syndrome is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic tissue growth factor (TGF)-β signaling. TGF-β is a potent regulator of the vascular smooth muscle cell (VSMC) phenotype. We hypothesized that as a result of the chronic TGF-β signaling, VSMC would alter their basal differentiation phenotype, which could facilitate the formation of aneurysms. This study explores whether… CONTINUE READING
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