Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension.

@article{Begum1998VascularSM,
  title={Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension.},
  author={Najma Begum and Yan Song and J Rienzie and Louis Ragolia},
  journal={The American journal of physiology},
  year={1998},
  volume={275 1 Pt 1},
  pages={C42-9}
}
Hyperinsulinemia (HI) and insulin resistance (IR) are frequently associated with hypertension and atherosclerosis. However, the exact roles of HI and IR in the development of hypertension are unclear. Mitogen-activated protein kinases (MAPK) are well-characterized intracellular mediators of cell proliferation. In this study, we examined the contribution of MAPK pathway in insulin-stimulated mitogenesis using primary vascular smooth muscle cells (VSMCs) isolated from aortas of normotensive… CONTINUE READING