Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium.

@article{Montezano2010VascularSM,
  title={Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium.},
  author={Augusto C. I. Montezano and Deborah K Zimmerman and H. Yusuf and Dylan Burger and Andr{\'e}ia Zago Chignalia and Vishal Wadhera and Frank N van Leeuwen and Rhian M Touyz},
  journal={Hypertension},
  year={2010},
  volume={56 3},
  pages={453-62}
}
Arterial calcification, common in vascular diseases, involves vascular smooth muscle cell (VSMC) transformation to an osteoblast phenotype. Clinical studies suggest that magnesium may prevent this, but mechanisms are unclear. We assessed whether increasing magnesium levels reduce VSMC calcification and differentiation and questioned the role of the Mg(2+) transporter, transient receptor potential melastatin (TRPM)7 cation channels in this process. Rat VSMCs were exposed to calcification medium… CONTINUE READING

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