Vascular smooth muscle cell activation and growth by 4-hydroxynonenal.

  title={Vascular smooth muscle cell activation and growth by 4-hydroxynonenal.},
  author={H Kakishita and Yoshiyuki Hattori},
  journal={Life sciences},
  volume={69 6},
The present study examines the signal transduction mechanism that is involved in the growth of vascular smooth muscle cells exposed to 4-hydroxynonenal (HNE) in vitro. This aldehyde component of oxidized low-density lipoprotein has been identified in atherosclerotic lesion. Exposure to HNE caused ERK, JNK, and p38 MAP kinase activation as well as the induction of c-fos and c-jun gene expression. AP-1 activity was also significantly induced by HNE treatment. These intracellular activities appear… CONTINUE READING


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