Vascular smooth muscle actin cytoskeleton in cerebral artery forced dilatation.

@article{Cipolla1998VascularSM,
  title={Vascular smooth muscle actin cytoskeleton in cerebral artery forced dilatation.},
  author={Marilyn J. Cipolla and George J Osol},
  journal={Stroke},
  year={1998},
  volume={29 6},
  pages={1223-8}
}
BACKGROUND AND PURPOSE We investigated the role of actin polymerization in regulating arterial diameter in response to increasing pressure and modulating forced dilatation of cerebral arteries at pressures above the upper limit of autoregulation. METHODS Posterior cerebral arteries (n = 12) were isolated and pressurized in a special arteriograph that allowed control of intravascular pressure and measurement of lumen diameter. Intact arteries in the absence (control) or presence of 3.0 mumol/L… CONTINUE READING

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Actin polymerization is induced by pressure in vascular smooth muscle cells and causes contraction of cerebral arteries

  • MJ Cipolla, G Osol
  • Circulation
  • 1997

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