Vascular responses to beta-adrenoceptor subtype-selective agonists with and without endothelium in rat common carotid arteries.

@article{Chiba2001VascularRT,
  title={Vascular responses to beta-adrenoceptor subtype-selective agonists with and without endothelium in rat common carotid arteries.},
  author={Shigetoshi Chiba and Miyoko Tsukada},
  journal={Journal of autonomic pharmacology},
  year={2001},
  volume={21 1},
  pages={7-13}
}
1. Using the cannula inserting method, vasodilator responses to beta-adrenoceptor agonists (isoprenaline, denopamine and procaterol) were investigated in isolated and perfused rat common carotid arteries. 2. Each beta-adrenoceptor agonist induced a vasodilation in preparations preconstricted by phenylephrine in a dose-related manner. The potencies were in the order of isoprenaline > procaterol >> denopamine. 3. Denopamine-induced dilations were significantly inhibited by 1 nmol betaxolol (a… CONTINUE READING