Vascular remodeling in transplant vasculopathy.

  title={Vascular remodeling in transplant vasculopathy.},
  author={Richard J. Mitchell and P. Scott Libby},
  journal={Circulation research},
  volume={100 7},
As therapeutic strategies to prevent acute rejection progressively improve, transplant vasculopathy (TV) constitutes the single most important limitation for long-term functioning of solid organ allografts. In TV, allograft arteries characteristically develop severe, diffuse intimal hyperplastic lesions that eventually compromise luminal flow and cause ischemic graft failure. Traditional immunosuppressive strategies that check acute allograft rejection do not prevent TV; indeed 50% of… CONTINUE READING


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: friends or foes

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