Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma.

@article{Semela2007VascularRA,
  title={Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma.},
  author={David Semela and A F Piguet and Mirjam Kolev and Karin Schmitter and Ruslan Hlushchuk and Valentin Djonov and Christoforos Stoupis and Jean-François Dufour},
  journal={Journal of hepatology},
  year={2007},
  volume={46 5},
  pages={840-8}
}
BACKGROUND/AIMS Hepatocellular carcinoma (HCC) is amenable to only few treatments. Inhibitors of the kinase mTOR are a new class of immunosuppressors already in use after liver transplantation. Their antiproliferative and antiangiogenic properties suggest that these drugs could be considered to treat HCC. We investigated the antitumoral effects of mTOR inhibition in a HCC model. METHODS Hepatoma cells were implanted into livers of syngeneic rats. Animals were treated with the mTOR inhibitor… CONTINUE READING

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