Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis.

@article{Becker2014VascularRA,
  title={Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis.},
  author={Mike Oliver Becker and Angela Kill and Marissa Kutsche and Jeannine Guenther and Angelika Rose and Christoph Tabeling and Martin Witzenrath and Anja Andrea K{\"u}hl and Harald Heidecke and Hossein Ardeschir Ghofrani and Henning Tiede and Ralph Theo Schermuly and N. M. Nickel and Marius M Hoeper and Ivo Lukitsch and Maik Gollasch and Wolfgang Michael Kuebler and Sebastian Bock and Gerd ‐ R{\"u}diger Burmester and Duska Dragun and Gabriela Riemekasten},
  journal={American journal of respiratory and critical care medicine},
  year={2014},
  volume={190 7},
  pages={808-17}
}
RATIONALE Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicated in PAH pathogenesis. OBJECTIVES We hypothesized that stimulating autoantibodies (Abs) targeting and activating AT1R and ETAR may contribute to SSc-PAH pathogenesis, and tested… CONTINUE READING