Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat.

@article{Linder2008VascularR5,
  title={Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat.},
  author={{\'A}urea Elizabeth Linder and Jessica Lorena Zambrano D{\'i}az and Wei Ni and Theo Szasz and Robert Burnett and Stephanie W Watts},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 4},
  pages={
          H1745-52
        }
}
The handling of serotonin [5-hydroxytryptamine (5-HT)] depends on the serotonin transporter (SERT). A SERT knockout (KO) rat is a useful model to test the hypothesis that SERT is the primary mechanism for arterial 5-HT uptake and to investigate the impact of SERT removal on blood pressure. Wild-type (WT) and KO rats were used to measure 5-HT content (plasma, raphe, aorta, carotid, and mesenteric artery), aortic isometric contraction, and blood pressure. HPLC supported the lack of circulating 5… CONTINUE READING

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