Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP - ribose

@inproceedings{Zhang2006VascularPO,
  title={Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP - ribose},
  author={Andrew Y. Zhang and Peipei Li},
  booktitle={Journal of cellular and molecular medicine},
  year={2006}
}
Cyclic ADP-ribose (cADPR) is a novel Ca(2+) mobilizing second messenger, which is capable of inducing Ca(2+) release from the sarcoplasmic reticulum (SR) via activation of ryanodine receptors (RyR) in vascular cells. This signaling nucleotide has also been reported to participate in generation or modulation of intracellular Ca(2+) sparks, Ca(2+) waves or oscillations, Ca(2+)- induced Ca(2+) release (CICR) and spontaneous transient outward currents (STOCs) in vascular smooth muscle cells (VSMCs… CONTINUE READING

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