Vascular pathology in the aged human brain

  title={Vascular pathology in the aged human brain},
  author={Lea Tenenholz Grinberg and Dietmar Rudolf Thal},
  booktitle={Acta Neuropathologica},
Cerebral atherosclerosis (AS), small vessel disease (SVD), and cerebral amyloid angiopathy (CAA) are the most prevalent arterial disorders in the aged brain. Pathogenetically, AS and SVD share similar mechanisms: plasma protein leakage into the vessel wall, accumulation of lipid-containing macrophages, and fibrosis of the vessel wall. CAA, on the other hand, is characterized by the deposition of the amyloid β-protein in the vessel wall. Despite these differences between CAA, AS and SVD… CONTINUE READING
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