Vascular parkinsonism: what makes it different?

@article{Gupta2011VascularPW,
  title={Vascular parkinsonism: what makes it different?},
  author={Deepak Gupta and Abraham C Kuruvilla},
  journal={Postgraduate Medical Journal},
  year={2011},
  volume={87},
  pages={829 - 836}
}
  • D. Gupta, A. Kuruvilla
  • Published 25 November 2011
  • Medicine, Psychology, Biology
  • Postgraduate Medical Journal
Vascular parkinsonism (VP) accounts for 2.5–5% of all cases of parkinsonism in various population based and clinical cohort studies. VP develops as a result of ischaemic cerebrovascular disease, so aetiologically it is classified as secondary parkinsonism. It has been variably referred to in the literature as arteriosclerotic parkinsonism, vascular pseudo-parkinsonism, and lower body parkinsonism. The most important consideration while making a diagnosis of VP should be to differentiate VP from… 
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TLDR
Current understanding of the clinical characteristics of VP, as well as knowledge gained from neuroimaging and nuclear imaging of the pathological features of VP are summarized, and consideration is given to whether the overlap between VP and Binswanger disease means that these two disorders should be considered as part of the same disease entity.
Vascular Parkinsonism and cognitive impairment: literature review, Brazilian studies and case vignettes
TLDR
Physicians are provided with an insight on the practical issues of VP, a disease potentially confounded with vascular dementia, idiopathic Parkinson's disease, dementia with Lewy bodies and other secondary causes of Parkinsonism.
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Vascular parkinsonism: a case series of 17 patients.
TLDR
This case series provides a profile of VP with predominant lower-limb involvement, freezing of gait and falls, pyramidal signs, executive dysfunction, concomitant vascular dementia, and poor levodopa response.
Jaw tremor: a manifestation of vascular parkinsonism? - a case report
TLDR
This case describes atypical clinical features which could be associated with VP including jaw tremor and stresses the importance of initiating a trial of levodopa as certain patients may respond well to medication.
Clinicoradiological comparison between vascular parkinsonism and Parkinson’s disease
TLDR
VP can be clinically distinguished from PD based on sudden onset of parkinsonism at an older age, characterised by lower body predominance, urinary incontinence, pyramidal signs, postural instability with freezing of gait and falls, and dementia.
Subclinical vascular disease and the risk of parkinsonism: The Rotterdam Study.
Clinical Application of Brain MRI in the Diagnostic Work-up of Parkinsonism
TLDR
The main purpose of brain MRI is to assess cerebrovascular damage, and to exclude other possible – and sometimes treatable – causes of parkinsonism, such as normal pressure hydrocephalus.
The Relationship of Clinical Treatment to Quality of Life in a Patient with Vascular Parkinsonism : A Case Report from a Pharmacist ’ s Perspective
TLDR
Physical activity may be useful for establishing a higher QoL in VP, and should have been started at the early-stage treatment, and further study is warranted on the use of multiple drugs in the elderly with VP.
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TLDR
Compared with PD, patients with parkinsonism associated with vascular disease are more likely to present with gait difficulty and postural instability rather than tremor, have a history of stroke and risk factors for stroke, and fail to respond to levodopa therapy.
Vascular parkinsonism: a distinct, heterogeneous clinical entity
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The differences in the clinical features support the concept that VP is a distinct clinical entity with heterogeneous clinical, MRI, and possibly pathophysiological features.
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TLDR
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