Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease.

@article{Cohen2010VascularOS,
  title={Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease.},
  author={Richard Alan Cohen and Xiaoyong Tong},
  journal={Journal of cardiovascular pharmacology},
  year={2010},
  volume={55 4},
  pages={308-16}
}
Vascular disease in hypertension and diabetes is associated with increased oxidants. The oxidants arise from NADPH oxidase, xanthine oxidase, and mitochondria. Superoxide anion and hydrogen peroxide are produced by both leukocytes and vascular cells. Nitric oxide is produced in excess by inducible nitric oxide synthase, and the potent oxidant, peroxynitrite, is formed from superoxide and nitric oxide. The damage to proteins caused by oxidants is selective, affecting specific oxidant-sensitive… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…