Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor (c-met).

@article{Wajih2002VascularOO,
  title={Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor (c-met).},
  author={Nadeem Wajih and Jennifer Walter and David C. Sane},
  journal={Circulation research},
  year={2002},
  volume={90 1},
  pages={46-52}
}
Hepatocyte growth factor (scatter factor) is an angiogenic growth factor that binds to its cellular transmembrane receptor, c-met. Both HGF and c-met are expressed by vascular smooth muscle and endothelial cells, where HGF may exert autocrine and paracrine effects. We have found that human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) release a soluble, truncated form of c-met. Receptor shedding was induced by treatment of the cells with phorbol 12… CONTINUE READING

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