Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

  title={Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance},
  author={Ingrid G Winkler and Val{\'e}rie Barbier and Bianca Nowlan and Rebecca N Jacobsen and Catherine E. Forristal and John T. Patton and John L. Magnani and J L{\'e}vesque},
  journal={Nature Medicine},
The microenvironment, or niche, surrounding a stem cell largely governs its cellular fate. Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone marrow, but a distinct function for each of these niches remains unclear. Here we report a new role for the adhesion molecule E-selectin expressed exclusively by bone marrow endothelial cells in the vascular HSC niche. HSC quiescence was enhanced and self-renewal potential was increased in E-selectin knockout (Sele… CONTINUE READING
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