Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement.

  title={Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement.},
  author={Panisadee Avirutnan and Nuntaya Punyadee and Sansanee Noisakran and Chulaluk Komoltri and Somchai Thiemmeca and Kusuma Auethavornanan and Aroonroong Jairungsri and Rattiyaporn Kanlaya and Nattaya Tangthawornchaikul and Chunya Puttikhunt and Sa-nga Pattanakitsakul and Pa-thai Yenchitsomanus and Juthathip Mongkolsapaya and Watchara Kasinrerk and Nopporn Sittisombut and Matthias Husmann and Maria Blettner and Sirijitt Vasanawathana and Sucharit Bhakdi and Prida Malasit},
  journal={The Journal of infectious diseases},
  volume={193 8},
BACKGROUND Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown. METHODS The major nonstructural dengue virus (DV) protein NS1 was tested for its capacity to activate human complement in its membrane-associated and soluble forms. Plasma samples from 163 patients with… 

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