Vascular leak in a rat model of preeclampsia.

@article{Uddin2009VascularLI,
  title={Vascular leak in a rat model of preeclampsia.},
  author={Mohammad Nasir Uddin and Luciana B McLean and Felicia A. Hunter and Darijana Horvat and Judson M Severson and B. D. Tharakan and Ed W. Childs and JulesB. Puschett},
  journal={American journal of nephrology},
  year={2009},
  volume={30 1},
  pages={
          26-33
        }
}
BACKGROUND/AIMS Preeclampsia is a hypertensive disorder which develops de novo in women during pregnancy. The urinary excretion of the cardiotonic steroid, marinobufagenin (MBG), is increased prior to the development of hypertension. Preeclamptic patients are volume expanded but much of the excess salt and water appears to be located primarily in the interstitial space. Therefore, 'capillary leak' syndrome has been postulated in this disorder. METHODS We evaluated the vascular leakage in… CONTINUE READING

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Marinobufagenin impairs proliferation and triggered enhanced vascular permeability in rat lung microvascular endothelial cells

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