Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine.

Abstract

PURPOSE We recently reported that anionic phospholipids, principally phosphatidylserine, become exposed on the external surface of vascular endothelial cells in tumors, probably in response to oxidative stresses present in the tumor microenvironment. In the present study, we tested the hypothesis that a chimeric monoclonal antibody that binds… (More)
DOI: 10.1158/1078-0432.CCR-07-1516

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@article{Jennewein2008VascularIO, title={Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine.}, author={Marc Jennewein and Matthew A. Lewis and Dawen Zhao and Edward N Tsyganov and Nikolai V Slavine and Jin He and Linda F. Watkins and Vikram D. Kodibagkar and Sean O'Kelly and Padmakar V. Kulkarni and Peter Antich and Alex Hermanne and Frank R{\"{o}sch and Ralph P. Mason and Philip E. Thorpe}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2008}, volume={14 5}, pages={1377-85} }