Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1.

@article{MoustafaBayoumi2007VascularHA,
  title={Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1.},
  author={Moustafa Moustafa-Bayoumi and Mazin A. Alhaj and Osama Hamed El-Sayed and Sheik Wisel and Maqsood Ahmed Chotani and Zeinb A. Abouelnaga and Mohamed Darwish Hessein Hassona and Katya Rigatto and Mariana Morris and Gerard J Nuovo and Jay L. Zweier and Pascal J. Goldschmidt-Clermont and Hamdy M. Hassanain},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 52},
  pages={
          37632-9
        }
}
We have overexpressed either the cDNA of human profilin 1 or expressed the mutant (88R/L) in the blood vessels of transgenic FVB/N mice. Reverse transcription-PCR indicated selective overexpression of profilin 1 and 88R/L in vascular smooth muscle cells. Polyproline binding showed increased profilin 1 and 88R/L proteins in transgenic mice compared with control (~30%, p < 0.05). Rhodamine-phalloidin staining revealed increase stress fiber formation in vascular smooth muscle cells of profilin 1… CONTINUE READING
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