Vascular graft endothelialization: comparative analysis of canine and human endothelial cell migration on natural biomaterials.

@article{Dixit2001VascularGE,
  title={Vascular graft endothelialization: comparative analysis of canine and human endothelial cell migration on natural biomaterials.},
  author={Pooja Dixit and Diane Hern-Anderson and John P. Ranieri and Christine Elizabeth Schmidt},
  journal={Journal of biomedical materials research},
  year={2001},
  volume={56 4},
  pages={
          545-55
        }
}
Canines are typically used as the standard preclinical model to gauge the success of vascular graft materials. However, canines spontaneously re-endothelialize vascular grafts, whereas humans do not, even after years. This raises questions of why there are differences in vascular healing between humans and other species and whether the canine is the appropriate preclinical model. In the present study we evaluated human and canine endothelial cell (EC) migration on the novel cross-linked… CONTINUE READING
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