Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism.

@article{Laurindo1994VascularFR,
  title={Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism.},
  author={Francisco R M Laurindo and Marcelo de Almeida Pedro and Hermes Vieira Barbeiro and F{\'u}lvio Pileggi and Maria Helena Catelli de Carvalho and Ohara Augusto and Prot{\'a}sio Lemos da Luz},
  journal={Circulation research},
  year={1994},
  volume={74 4},
  pages={700-9}
}
Mechanisms underlying production of vascular free radicals are unclear. We hypothesized that changes in blood flow might serve as a physiological stimulus for endothelial free radical release. Intact isolated aortas from 45 rabbits were perfused with the spin trap alpha-phenyl-N-tert-butylnitrone (PBN, 20 mmol/L) and formed radical adducts detected by electron paramagnetic resonance spectroscopy (EPR). Sequential perfusion at 2, 7.5, and 12 mL/min changed cumulative vascular PBN radical adduct… CONTINUE READING

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