Vascular factors in the neurotoxic damage caused by 1,3-dinitrobenzene in the rat.

@article{Romero1991VascularFI,
  title={Vascular factors in the neurotoxic damage caused by 1,3-dinitrobenzene in the rat.},
  author={Ivan Romero and Allen W. Brown and John B. Cavanagh and Christopher C. Nolan and David E. Ray and M P Seville},
  journal={Neuropathology and applied neurobiology},
  year={1991},
  volume={17 6},
  pages={495-508}
}
Using a 3 x 10 mg/kg dose schedule of 1,3-dinitrobenzene (DNB) over two days in Fischer rats, we have found the following changes in vascular function and structure during the early phase of the symmetrical brain stem lesions. 1. Marked increase in cerebral blood flow generally but especially in the inferior colliculi, from 6 h after the final dose of DNB. 2. Increasing incidence of petechial haemorrhages in inferior colliculi, cerebellar roof, vestibular and superior olivary nuclei from 12 h… CONTINUE READING

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