Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation.

@article{Landmesser2000VascularES,
  title={Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation.},
  author={Ulf Landmesser and Richard Merten and Stephan Spiekermann and Kerstin B{\"u}ttner and Helmut Drexler and Burkhard Hornig},
  journal={Circulation},
  year={2000},
  volume={101 19},
  pages={2264-70}
}
BACKGROUND Increased inactivation of nitric oxide by oxygen free radicals contributes to endothelial dysfunction in patients with coronary artery disease (CAD). We therefore determined the activity of extracellular superoxide dismutase (EC-SOD), the major antioxidant enzyme system of the vessel wall, and its relation to flow-dependent, endothelium-mediated dilation (FDD) in patients with CAD. METHODS AND RESULTS SOD isoenzyme activity was determined in coronary arteries from 10 patients with… CONTINUE READING
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