Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.

  title={Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.},
  author={Michael A. Gimbrone and Guillermo Garc{\'i}a-Carde{\~n}a},
  journal={Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology},
  volume={22 1},
The localization of atherosclerotic lesion formation to regions of disturbed blood flow associated with certain arterial geometries, in humans and experimental animals, suggests an important role for hemodynamic forces in the pathobiology of atherosclerosis. There is increasing evidence that the vascular endothelium, which is directly exposed to various fluid mechanical forces generated by pulsatile blood flow, can discriminate among these different biomechanical stimuli and transduce them into… CONTINUE READING

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