Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis.

@article{Koch1994VascularEG,
  title={Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis.},
  author={Alisa Erika Koch and Lisa A Harlow and G. Kenneth Haines and Edward P. Amento and Elaine N Unemori and Wai Lee Wong and Richard M. Pope and Napoleone M. A. Ferrara},
  journal={Journal of immunology},
  year={1994},
  volume={152 8},
  pages={4149-56}
}
Angiogenesis is important in the proliferation of inflammatory synovial tissue. Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that is also angiogenic in vivo. We examined the potential role of VEGF in mediating chemotaxis and proliferation of endothelial cells in rheumatoid arthritis (RA) using samples of synovial tissue and synovial fluid from 55 arthritic patients. Synovial fluid VEGF by ELISA was higher in RA synovial fluids (386 +/- 122 ng/ml) (SE) compared with… CONTINUE READING

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