Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.

Abstract

Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)-independent Raf-1-MEK-extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.

8 Figures and Tables

0200400'02'04'06'08'10'12'14'16
Citations per Year

3,047 Citations

Semantic Scholar estimates that this publication has 3,047 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Podar2001VascularEG, title={Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.}, author={Klaus Podar and Y T Tai and F E Davies and Suzanne Lentzsch and Martin Sattler and Teru Hideshima and Boris K Lin and Dheeraj Gupta and Yasuko Shima and Dharminder Chauhan and Constantine Mitsiades and Noopur S. Raje and P G G Richardson and K C Anderson}, journal={Blood}, year={2001}, volume={98 2}, pages={428-35} }