Vascular endothelial growth factor stimulates the primary to secondary follicle transition in bovine follicles in vitro.

@article{Yang2007VascularEG,
  title={Vascular endothelial growth factor stimulates the primary to secondary follicle transition in bovine follicles in vitro.},
  author={Minghui Yang and Joanne E. Fortune},
  journal={Molecular reproduction and development},
  year={2007},
  volume={74 9},
  pages={1095-104}
}
Little is known about the mechanisms regulating the growth of early preantral follicles, especially in nonrodent mammalian species. To test the hypothesis that vascular endothelial growth factor (VEGF) promotes the primary to secondary follicle transition, pieces of bovine fetal ovarian cortex were cultured with VEGF (0, 1, 10, or 100 ng/ml) for 0 or 10 days, followed by morphometric analysis. On day 0, cortical pieces contained mostly primordial follicles, but after 10 days in vitro most… CONTINUE READING