Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism.

@article{Gaudio2006VascularEG,
  title={Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism.},
  author={Eugenio Gaudio and Barbara Barbaro and Domenico Alvaro and Shannon S. Glaser and Heather Francis and Yoshiyuki Ueno and Cynthia Meininger and Antonio Franchitto and Paolo Onori and Marco Marzioni and Silvia Taffetani and Giammarco Fava and George Stoica and Julie K Venter and Ramona Reichenbach and Sharon De Morrow and Ryun Summers and Gianfranco D Alpini},
  journal={Gastroenterology},
  year={2006},
  volume={130 4},
  pages={1270-82}
}
BACKGROUND & AIMS Vascular endothelial growth factor (VEGF) is secreted by several epithelia and modulates cellular functions by autocrine and paracrine mechanisms. The role of VEGF in cholangiocyte pathophysiology is unknown. We evaluated the role of VEGF in the regulation of cholangiocyte proliferation in rats that underwent bile duct ligation. METHODS The expression of VEGF-A and VEGF-C and their receptors in cholangiocytes from normal and BDL rats was evaluated. Normal or BDL rats were… CONTINUE READING

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