Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.

@article{Dragoni2011VascularEG,
  title={Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.},
  author={Silvia Dragoni and Umberto Laforenza and Elisa Bonetti and Francesco Lodola and Cinzia Bottino and Roberto Berra-Romani and Giacomo Carlo Bongio and Maria Pia Cinelli and Germano Guerra and Paolo Pedrazzoli and Vittorio Rosti and Franco Tanzi and Francesco Moccia},
  journal={Stem cells},
  year={2011},
  volume={29 11},
  pages={
          1898-907
        }
}
Endothelial progenitor cells (EPCs) home from the bone marrow to the site of tissue regeneration and sustain neovascularization after acute vascular injury and upon the angiogenic switch in solid tumors. Therefore, they represent a suitable tool for cell-based therapy (CBT) in regenerative medicine and provide a novel promising target in the fight against cancer. Intracellular Ca(2+) signals regulate numerous endothelial functions, such as proliferation and tubulogenesis. The growth of… CONTINUE READING
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