Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts.

@article{Sondell1999VascularEG,
  title={Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts.},
  author={Mariann Sondell and G{\"o}ran Lundborg and Martin Kanje},
  journal={Brain research},
  year={1999},
  volume={846 2},
  pages={219-28}
}
The aim of this study was to investigate the effects of vascular endothelial growth factor (VEGF) on regeneration of the rat sciatic nerve in vivo. To that end we used 10-mm long cell-free nerve grafts to bridge a gap in the sciatic nerve. The grafts were pretreated with either VEGF (50, 100 or 250 ng/ml), nerve growth factor (NGF, 100 ng/ml) or laminin (100 ng/ml) before implantation. Outgrowth of axons, Schwann cells, blood vessels and macrophages were studied 10 days post-implantation by the… CONTINUE READING

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