Vascular endothelial growth factor stimulates a novel calcium-signaling pathway in vascular smooth muscle cells.

@article{Chandra2005VascularEG,
  title={Vascular endothelial growth factor stimulates a novel calcium-signaling pathway in vascular smooth muscle cells.},
  author={Ankur Chandra and Niren Angle},
  journal={Surgery},
  year={2005},
  volume={138 4},
  pages={780-7}
}
BACKGROUND Vascular endothelial growth factor (VEGF) is a potent vascular mitogen that selectively stimulates vascular smooth muscle cell (VSMC) migration through an unknown mechanism while having no effect on VSMC proliferation. It is known that VSMC migration and proliferation are dependent on the second messenger Ca2+ and, in particular, mitogen-stimulated Ca2+ influx. We hypothesized that the selective effect of VEGF on VSMC migration versus proliferation was a result of differential VEGF… CONTINUE READING