Vascular endothelial growth factor regulates germ cell survival during establishment of spermatogenesis in the bovine testis.

@article{Caires2009VascularEG,
  title={Vascular endothelial growth factor regulates germ cell survival during establishment of spermatogenesis in the bovine testis.},
  author={Kyle C. Caires and Jeanene de Avila and D J Mclean},
  journal={Reproduction},
  year={2009},
  volume={138 4},
  pages={
          667-77
        }
}
Vascular endothelial growth factor-A (VEGFA) is a hypoxia-inducible peptide essential for angiogenesis and targets nonvascular cells in a variety of tissues and cell types. The objective of the current study was to determine the function of VEGF during testis development in bulls. We used an explant tissue culture and treatment approach to test the hypothesis that VEGFA-164 could regulate the biological activity of bovine germ cells. We demonstrate that VEGFA, KDR, and FLT1 proteins are… CONTINUE READING
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