Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development.

  title={Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development.},
  author={Ingrid Nilsson and Charlotte Rolny and Yan Wu and Bronislaw Pytowski and Dan J Hicklin and Kari Alitalo and Lena Claesson-Welsh and Stefan Wennstr{\"o}m},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={18 13},
Reduced tissue oxygen tension (hypoxia) is appreciated as an efficient stimulus for neovascularization. The effect of hypoxia on the very first stages of vascular development is, however, less well characterized. Here we show that hypoxic conditions (1% O2) potently stimulated formation of an extensive vascular network during a discrete stage of mouse embryonal stem cell differentiation. The morphological changes correlated with an expanding pool of endothelial cells and with activation of the… CONTINUE READING
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