Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E.

@article{Shibuya2003VascularEG,
  title={Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E.},
  author={Masabumi Shibuya},
  journal={Cancer science},
  year={2003},
  volume={94 9},
  pages={751-6}
}
Vascular endothelial growth factor receptor-2 (VEGFR-2/KDR/Flk-1) is a high-affinity receptor for vascular endothelial growth factor-A (VEGF-A), and mediates most of the endothelial growth and survival signals from VEGF-A. VEGFR-2 has a typical tyrosine kinase receptor structure with seven immunoglobulin (Ig)-like domains in the extracellular region, as well as a long kinase insert in the tyrosine kinase domain. It utilizes a unique signaling system for DNA synthesis in vascular endothelial… CONTINUE READING
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