Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.

@article{Holmes2007VascularEG,
  title={Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.},
  author={Katherine D. Holmes and Owain Ll Roberts and Angharad Mair Thomas and Michael J Cross},
  journal={Cellular signalling},
  year={2007},
  volume={19 10},
  pages={
          2003-12
        }
}
Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades… CONTINUE READING
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