Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.

@article{Melnyk1996VascularEG,
  title={Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.},
  author={Oksana Melnyk and Marc A. Shuman and Kyungjae J Kim},
  journal={Cancer research},
  year={1996},
  volume={56 4},
  pages={921-4}
}
Tumor growth is dependent on new blood vessel formation. Inhibition of vascular endothelial growth factor (VEGF), an endothelial cell mitogen and angiogenic factor secreted by a variety of tumors and tumor cell lines, is sufficient to inhibit primary tumor growth. In the present study, we examined the effect of inhibiting VEGF on tumor cell micrometastasis. A transfectant of A431 (a human epidermoid carcinoma cell line) expressing chloramphenicol acetyltransferase (CAT) was injected s.c. into… CONTINUE READING