Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis.

@article{Furumatsu2003VascularEG,
  title={Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis.},
  author={Takayuki Furumatsu and Zheng Nan Shen and Akira Kawai and Keiichiro Nishida and Hironori Manabe and Toshitaka Oohashi and Hajime Inoue and Yoshifumi Ninomiya},
  journal={Journal of biochemistry},
  year={2003},
  volume={133 5},
  pages={
          633-9
        }
}
Vascular endothelial growth factor (VEGF)-mediated angiogenesis is essential for bone formation. However, the effect of VEGF on osteoblastic cells during osteoblastogenesis is still controversial. The aim of this study was to clarify the relationship between osteoblastic cells derived from human mesenchymal stem cells (MSCs) and VEGF in the early stage of osteoblastic differentiation. Continuous dexamethasone treatment with a low concentration stimulated osteoblastogenesis of MSCs and the… CONTINUE READING
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