Vascular endothelial growth factor polymorphisms -1154 G/A and -460 C/T are not associated with VEGF mRNA expression and susceptibility to sporadic colon cancer.

@article{Cacev2008VascularEG,
  title={Vascular endothelial growth factor polymorphisms -1154 G/A and -460 C/T are not associated with VEGF mRNA expression and susceptibility to sporadic colon cancer.},
  author={Tamara Cacev and Bo{\vz}o Lon{\vc}ar and Sven Seiwerth and Sime Spaventi and Sanja Kapitanovic},
  journal={DNA and cell biology},
  year={2008},
  volume={27 10},
  pages={569-74}
}
Vascular endothelial growth factor (VEGF) is important mediator of angiogenesis, and its expression in colorectal tumors is related to tumor progression. VEGF expression has been detected in normal mucosa, primary colon cancers, and metastatic tumors, and patients with low VEGF expression have a better survival rate. In addition, anti-VEGF monoclonal antibody improves overall survival when used in combination with existing metastatic colorectal cancer therapy. Therefore, prediction of VEGF… CONTINUE READING

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