Vascular endothelial growth factor modulates voltage-gated Na(+) channel properties and depresses action potential firing in cultured rat hippocampal neurons.


Vascular endothelial growth factor (VEGF), an angiogenic factor, was found to modulate synaptic plasticity by affecting K(+) and Ca(2+) channels and protect neuron from death by depressing glutamatergic transmission. However, whether VEGF also modulates neuronal activity through modulating voltage-gated Na(+) channels (VGSCs), a main determinant of neuronal… (More)


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