Vascular endothelial growth factor level correlates with transforming growth factor-beta isoform levels in pleural effusions.

@article{Cheng2000VascularEG,
  title={Vascular endothelial growth factor level correlates with transforming growth factor-beta isoform levels in pleural effusions.},
  author={David Y. Cheng and Y C Gary Lee and Jeffrey T Rogers and Elizabeth A Perkett and J Phillip Moyers and R Michael Rodriguez and Richard W. Light},
  journal={Chest},
  year={2000},
  volume={118 6},
  pages={1747-53}
}
BACKGROUND Recent studies have demonstrated high levels of vascular endothelial growth factor (VEGF) in exudative pleural effusions and a possible etiologic role. The factors regulating VEGF accumulation in the pleural space are unknown. Transforming growth factor (TGF)-beta is a potent stimulator of VEGF expression in vitro. We hypothesized that TGF-beta induces VEGF production in pleural tissues, and, hence, the pleural fluid VEGF levels should correlate with the levels of TGF-beta in pleural… CONTINUE READING
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