Vascular endothelial growth factor isoform expression as a determinant of blood vessel patterning in human melanoma xenografts.

@article{Yu2002VascularEG,
  title={Vascular endothelial growth factor isoform expression as a determinant of blood vessel patterning in human melanoma xenografts.},
  author={Joanne L. Yu and Janusz Rak and Giannoula Klement and Robert S. Kerbel},
  journal={Cancer research},
  year={2002},
  volume={62 6},
  pages={1838-46}
}
Vascular endothelial growth factor (VEGF) occurs in at least five different isoforms because of alternative splicing of the gene. To investigate the roles of different VEGF isoforms in tumor blood vessel formation and tumorigenicity, the three major isoforms (VEGF(121), VEGF(165), and VEGF(189)) were overexpressed in an early-stage human melanoma cell line (WM1341B), which is VEGF-negative and nontumorigenic in immunodeficient mice. Although overexpression of VEGF(121) and VEGF(165) resulted in… CONTINUE READING