Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure.

@article{Westenbrink2010VascularEG,
  title={Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure.},
  author={B. Daan Westenbrink and W T Ruifrok and Adriaan Alexander Voors and Ronald G. Tilton and Dirk Jan van Veldhuisen and Regien Geertruida Schoemaker and Wiek H van Gilst and Rudolf A de Boer},
  journal={Cardiovascular research},
  year={2010},
  volume={87 1},
  pages={30-9}
}
AIMS We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial growth factor (VEGF) production and to establish if VEGF is crucial for EPO-induced improvement of cardiac performance. METHODS AND RESULTS The effects of EPO on VEGF expression were studied in cultured cardiac cells and EPO-treated hearts. The role of VEGF in EPO-induced neovascularization was studied with two distinct VEGF-neutralizing antibodies or irrelevant control IgG in an aortic… CONTINUE READING

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Anaemia in chronic heart failure: etiology and treatment options

BD Westenbrink, RA de Boer, AA Voors, WH van Gilst, DJ. van Veldhuisen
Curr Opin Cardiol • 2008
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