Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma.

@article{Strizzi2001VascularEG,
  title={Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma.},
  author={Luigi Strizzi and Alfonso Catalano and Giovina Vianale and Sara Orecchia and Angelo Gianni Casalini and Gian Franco Tassi and Riccardo Puntoni and Luciano Mutti and Ant{\^o}nio Eduardo Proc{\'o}pio},
  journal={The Journal of pathology},
  year={2001},
  volume={193 4},
  pages={468-75}
}
Vascular endothelial growth factor (VEGF), a potent mitogen for vascular endothelium, is expressed in malignant pleural mesothelioma (MM). The present report examines the effect of VEGF on MM growth. Four MM cell lines produced significantly higher VEGF levels than normal mesothelial cells (1946+/-14 pg/ml vs. 180+/-17 pg/ml; p<0.001). In addition, MM cells expressed the tyrosine kinase-related VEGF receptors Flt-1 and KDR. Recombinant human VEGF phosphorylated both Flt-1 and KDR and increased… CONTINUE READING
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