Corpus ID: 6999198

Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor.

@article{Katoh1998VascularEG,
  title={Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor.},
  author={O Katoh and Toshitada Takahashi and Tetsuya Oguri and Ken Kuramoto and Keiichiro Mihara and M. Kobayashi and Shitau Hirata and Hideomi Watanabe},
  journal={Cancer research},
  year={1998},
  volume={58 23},
  pages={
          5565-9
        }
}
We reported previously that vascular endothelial growth factor (VEGF) inhibits the apoptotic death of hematopoietic cells that is induced by exposure to ionizing radiation (O. Katoh et al., Cancer Res., 55: 5687-5692, 1995). In this study, we show that VEGF also inhibits apoptotic cell death that is induced by exposure to the chemotherapeutic drugs etoposide and doxorubicin. To elucidate the molecular mechanisms underlying this inhibitory effect of VEGF, we examined expression levels of BCL2… Expand
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