Vascular endothelial growth factor inhibitors and cognitive impairment: evidence and controversies.

@article{Ng2014VascularEG,
  title={Vascular endothelial growth factor inhibitors and cognitive impairment: evidence and controversies.},
  author={Terence Ng and Yin Ting Cheung and Q. S. Ng and Han Kiat Ho and Alexandre Chan},
  journal={Expert opinion on drug safety},
  year={2014},
  volume={13 1},
  pages={83-92}
}
INTRODUCTION Chemotherapy-induced cognitive impairment, or 'chemobrain,' has been well established in the literature. However, neurocognitive toxic effect induced by targeted therapies such as anti-angiogenic agents is poorly investigated. Recently, emerging evidence suggests vascular endothelial growth factor (VEGF) to have a possible role in brain cognition giving rise to concerns whether VEGF inhibitors (VEGFIs) may induce neurotoxic effect on cancer patients' cognitive function. AREAS… CONTINUE READING

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