Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease

@article{Kim2004VascularEG,
  title={Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease},
  author={Hyun-Joong Kim and Shin Yi Jang and Joong-Il Park and Jonghoe Byun and Dong-ik Kim and Y H Do and J Kim and Sunyoung Kim and B Kim and Won-Bae Kim and Duk-Kyung Kim},
  journal={Experimental & Molecular Medicine},
  year={2004},
  volume={36},
  pages={336-344}
}
This phase 1 clinical trial tested the safety of intramuscular gene transfer by using naked plasmid DNA encoding the gene for VEGF, and analyzed the potential therapeutic benefits in patients with severe peripheral arterial disease (PAD). This study was an open-labeled, dose- escalating, single-center trial on nine male patients with severe debilitating PAD who had not responded to conventional therapy. Seven had Buerger's disease and two had arteriosclerosis obliterans. Plasmid DNA (pCK… CONTINUE READING