Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway.

@article{Bates1997VascularEG,
  title={Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway.},
  author={David W Bates and Fitz-Roy Curry},
  journal={The American journal of physiology},
  year={1997},
  volume={273 2 Pt 2},
  pages={
          H687-94
        }
}
We tested the hypothesis that vascular endothelial growth factor (VEGF) increases microvascular permeability by increasing calcium influx into endothelial cells forming the vessel walls. We measured microvessel hydraulic conductivity (Lp) in isolated perfused MS-222-anesthetized frog mesenteric microvessels during perfusion with VEGF under conditions that attenuate calcium influx. VEGF increased Lp during a second successive perfusion in the same microvessel by 7.8-fold, which was not… CONTINUE READING
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